Gastroprotective Effect of Radish “raphanus Sativus” L. on Experimental Gastric Ulcer Models in Rats

Raphanus sativus L. ‘Radish’ locally known as Fijl, is a Brassicaceous plant of cabbage family which has been reputed for its benefic medicinal properties. The present study was undertaken to evaluate the freshly squeezed Radish juice (FRJ) for its anti-gastric ulcer activity in experimental models, besides preliminary qualitative phytochemical screening. Oral administration of FRJ in doses of 2 and 4 ml/ 200 g b.w. significantly inhibited gastric ulcer formation induced by necrotizing agents (ethanol, sodium hydroxide and sodium chloride) hypothermic restraint-stress and indomethacin. The FRJ also replenished the ethanol induced depleted gastric wall mucus secretion and nonproteinsulfhydryl (NP-SH) concentrations in rats. The phytochemical screening showed the presence of flavonoids, anthocyanins and sulfurated constituents. In conclusion, the results indicate that the fresh juice of Radish possesses gastroprotective potential related to the mucus secretion stimulation (potentiation of defensive factors); and increase in NP-SH concentration is probably due to prostaglandin-inducing abilities, mediated through its antioxidant activity. Rezumat Raphanus sativus L. (Fam. Brasicaceae), hrean, este o plantă utilizată în medicina tradiŃională pentru proprietăŃile sale terapeutice deosebite. Lucrarea prezintă rezultatele unor studii experimentale, efectuate pe animale de laborator (şobolani albi), de testare a acŃiunii antiulceroase a sucului proaspăt extras din această plantă. Efectul farmacologic a fost urmărit în diferite condiŃii experimentale: ulcer indus prin factori necrozanŃi (etanol, hidroxid de sodiu, clorură de sodiu), ulcer de stres şi ulcer indus prin administrare de indometacin. • Gastroprotection • Radish • Raphanus sativus